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. 2023 Mar 31;13:5258. doi: 10.1038/s41598-023-31730-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Normalized PRSs for ten significant genera between AD cases and controls in the discovery sample. (A) PRSs for six genera were relatively lower in AD cases than controls (p < 0.05), suggesting they might be a protective factor for AD. (B) PRSs for four genera were relatively higher in AD cases vs. controls (p < 0.05), suggesting they were likely be a risk factor for AD. Wilcoxon Rank Sum test was applied to generate p values. X-axis: Diagnosis (AD cases/controls). Y-axis: z-score normalized PRSs for each of the ten significant genera.