Table 4.
Association between PRSs for ten significant gut microbiota genera and APOE rs429358.
| Trait | Samples | Coeff | SE | z-value | P | OR (95%CI) |
|---|---|---|---|---|---|---|
| Adlercreutzia | ADc12 | − 0.051 | 0.031 | − 1.643 | 0.1006 | 0.95 (0.89–1.01) |
| GenADA | − 0.093 | 0.040 | − 2.309 | 0.0211 | 0.91 (0.84–0.99) | |
| Meta-analysis | − 0.067 | 0.025 | − 2.712 | 0.0067 | 0.94 (0.89–0.98) | |
| Bacteroides | ADc12 | 0.019 | 0.031 | 0.608 | 0.5434 | 1.02 (0.96–1.08) |
| GenADA | 0.014 | 0.040 | 0.350 | 0.7263 | 1.01 (0.94–1.10) | |
| Meta-analysis | 0.017 | 0.025 | 0.695 | 0.4871 | 1.02 (0.97–1.07) | |
| Collinsella | ADc12 | 0.137 | 0.031 | 4.413 | 1.06E-5 | 1.15 (1.08–1.22) |
| GenADA | 0.118 | 0.040 | 2.930 | 0.0034 | 1.12 (1.04–1.22) | |
| Meta-analysis | 0.130 | 0.025 | 5.283 | 1.27E-7 | 1.14 (1.09–1.19) | |
| Eisenbergiella | ADc12 | − 0.105 | 0.031 | − 3.382 | 0.0007 | 0.90 (0.85–0.96) |
| GenADA | 0.007 | 0.040 | 0.180 | 0.8575 | 1.01 (0.93–1.09) | |
| Meta-analysis | − 0.052 | 0.056 | − 0.924 | 0.3553 | 0.95 (0.85–1.06) | |
| Eubacterium Fissicatena | ADc12 | − 0.111 | 0.031 | − 3.557 | 0.0004 | 0.90 (0.84–0.95) |
| GenADA | − 0.010 | 0.040 | − 0.252 | 0.8011 | 0.99 (0.91–1.07) | |
| Meta-analysis | − 0.064 | 0.050 | − 1.270 | 0.2042 | 0.94 (0.85–1.04) | |
| Eubacterium Nodatum | ADc12 | − 0.097 | 0.031 | − 3.130 | 0.0018 | 0.91 (0.85–0.96) |
| GenADA | − 0.043 | 0.040 | − 1.080 | 0.2804 | 0.96 (0.88–1.04) | |
| Meta-analysis | − 0.077 | 0.026 | − 2.912 | 0.0036 | 0.93 (0.88–0.98) | |
| Gordonibacter | ADc12 | − 0.108 | 0.031 | − 3.460 | 0.0005 | 0.90 (0.84–0.95) |
| GenADA | − 0.014 | 0.040 | − 0.352 | 0.7248 | 0.99 (0.91–1.07) | |
| Meta-analysis | − 0.064 | 0.047 | − 1.383 | 0.1668 | 0.94 (0.86–1.03) | |
| Lachnospira | ADc12 | 0.047 | 0.031 | 1.524 | 0.1277 | 1.05 (0.99–1.11) |
| GenADA | 0.047 | 0.040 | 1.169 | 0.2425 | 1.05 (0.97–1.13) | |
| Meta-analysis | 0.047 | 0.025 | 1.921 | 0.0548 | 1.05 (1.00–1.10) | |
| Prevotella9 | ADc12 | − 0.046 | 0.031 | − 1.486 | 0.1373 | 0.95 (0.90–1.01) |
| GenADA | − 0.074 | 0.040 | − 1.836 | 0.0666 | 0.93 (0.86–1.01) | |
| Meta-analysis | − 0.057 | 0.025 | − 2.299 | 0.0215 | 0.94 (0.90–0.99) | |
| Veillonella | ADc12 | 0.092 | 0.031 | 2.946 | 0.0032 | 1.10 (1.03–1.17) |
| GenADA | − 0.027 | 0.040 | − 0.664 | 0.5071 | 0.97 (0.90–1.05) | |
| Meta-analysis | 0.035 | 0.059 | 0.596 | 0.5513 | 1.04 (0.92–1.16) |
Genera in bold are four genera identified to have genetically significant correlation with APOE rs429358 minor allele C in the meta-analysis (p < 0.05). Collinsella was the only genus that showed significant correlation in both discovery and replication samples.