Table 5.

List of gut microbiome genera that were nominally associated with APOE SNPs rs429358 and rs7412.

rsID (CHR:BP:Effect Allele)	Microbiome Genera	Beta	SE	SZ	P	N	# cohorts
rs429358 (19:45411941:C)	Bacteroides	− 0.044	0.015	− 2.881	0.0040	18173	23
	Butyricimonas	− 0.044	0.020	− 2.241	0.0250	10657	23
	Dorea	0.030	0.015	2.127	0.0334	17494	23
	Eubacterium coprostanoligenes	0.033	0.015	2.120	0.0340	17261	23
	Faecalibacterium	− 0.035	0.015	− 2.188	0.0287	17960	23
	Olsenella	0.064	0.033	1.993	0.0462	3721	13
	Parasutterella	0.040	0.019	2.216	0.0267	11291	23
	Senegalimassilia	0.050	0.024	2.207	0.0273	6888	21
	Veillonella	0.044	0.021	2.032	0.0421	9194	23
rs7412 (19:45412079:T)	Butyricicoccus	0.048	0.021	2.468	0.0136	15637	20
	Collinsella	0.052	0.023	2.214	0.0268	12811	19
	Coprococcus3	0.050	0.022	2.344	0.0191	14323	20
	Eubacterium hallii	0.053	0.021	2.453	0.0142	14846	20
	Lachnospiraceae UCG001	− 0.071	0.027	− 2.534	0.0113	9357	20
	Olsenella	− 0.103	0.043	− 2.346	0.0190	3721	13
	Ruminococcaceae UCG004	0.080	0.028	2.901	0.0037	9049	20
	Senegalimassilia	0.082	0.032	2.584	0.0098	6508	18

SNP data were extracted from GWAS summary statistics of human gut microbiome abundance conducted from 24 multi-ethnic cohorts in the MiBioGen consortium (www.mibiogen.org)²⁴. rsID (CHR:BP:Effect Allele): the rs number of single nucleotide polymorphisms, chromosome number (CHR), base pair (BP), with the effect allele (genome assembly GRCh37/hg19). Microbiome: the genus level with significant abundance associated with APOE two SNPs. Beta: Beta coefficient. SE: Standard Error. SZ: Weighted sum of z-scores. P: p-value (p < 0.05 was considered as nominal association between the microbiome genera and APOE). N: sample count. # Cohorts: Number of cohorts involved.