Figure 10.

Tumor inhibition effect of Clo or Can in xenograft mouse model in vivo. NSG mice were xenografted with mycoplasma-free cancer cells subcutaneously (1 × 10⁷ PANC1, 3 × 10⁶ HT29). When tumor volumes reached ∼50 mm³ mice were treated with either vehicle control (10% DMSO, 20% PEG400, 5% Tween 80 and 65% sterile water), or 100 mg/kg Clo or Can through oral gavage daily. Tumor volumes were measured daily following the first week and body weights were measured twice a week. ∗P < 0.05 vehicle vs. 100 mg/kg Clo, ∗P < 0.05 vehicle vs. 100 mg/kg Can.