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. 2023 Mar 31;9(1):5. doi: 10.1038/s41514-023-00102-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a AAV-GfaABC1D-mito7-eGFP was injected into the DLS of young and aging mice. 3 weeks later, striatal sections were imaged to obtain single plane images of mitochondria in AQP4 labeled BVs. b Representative single plane confocal images from the DLS of young (left) and aging (right) mice expressing AAV-GfaABC1D-mito7-eGFP (green) and stained with AQP4 (red), scale bar = 15 μm. c Bar graph comparing the number of mitochondria in AQP4 labeled BVs (left) and AQP4 intensity (right) in young and aging mice. d Representative z-stacks of blood vessels labeled with AQP4 in the DLS of young (left) and aging (right) mice, scale bar = 150 μm. e Bar graph comparing the number of AQP4 labeled blood vessels in young and aging mice. For mitochondria counting and AQP4 intensity, young mice n = 38 blood vessels from 9 striatal sections and 3 mice and aging mice: n = 49 blood vessels from 9 striatal sections and 3 mice per age group. Error bars are S.E.M, p values are based on Mann-Whitney tests. For the number of AQP4 blood vessels, n = 6 DLS FOV from 3 mice each for young and aging mice. Error bars are S.E.M. and the p value is based on a two-sample t-test.