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. 2023 Mar 31;14:1796. doi: 10.1038/s41467-023-37409-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Volcano plots of the differential alternative splicing events identified in E13.5 Nfatc1-Cre;Ptbp1^fl/fl hearts and Cdh5-CreERT2;Ptbp1^fl/fl hearts compared with Ptbp1^fl/fl hearts, respectively. Significant alternative splicing events (FDR < 0.05 and | ΔPSI | ≥ 0.2) are colored as blue and red dots if Ptbp1 deletion results in skipping or inclusion, respectively. n = 2–4 mice per group. PSI percent spliced in. b Violin plot of the distributions of differential alternative splicing event types in Nfatc1-Cre;Ptbp1^fl/fl and Cdh5-CreERT2;Ptbp1^fl/fl hearts, respectively. A3SS alternative 3’ splice site, A5SS alternative 5’ splice site, MXE mutually exclusive exon, RI retention intron, SE skipped exon. c Stacked bar graph showing the proportions of different types of differential alternative splicing events in Nfatc1-Cre;Ptbp1^fl/fl and Cdh5-CreERT2;Ptbp1^fl/fl hearts, respectively. d Gene Ontology (GO) enrichment analysis of genes with differential skipping exon (SE) events in Nfatc1-Cre;Ptbp1^fl/fl and Cdh5-CreERT2;Ptbp1^fl/fl hearts, respectively. GO analysis were performed using R package clusterProfiler. e Venn diagram showing the common significant SE events between Nfatc1-Cre;Ptbp1^fl/fl and Cdh5-CreERT2;Ptbp1^fl/fl hearts. Exons are required to change in the same direction to appear at the intersection of the two sets. f Circular plot showing the selected functional categories of common genes with differential SE events in E13.5 Nfatc1-Cre;Ptbp1^fl/fl and Cdh5-CreERT2;Ptbp1^fl/fl hearts. Source data are provided as a Source Data file.