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. 2023 Feb 17;33(4):273–287. doi: 10.1038/s41422-023-00782-7

Fig. 3. Famsin promotes torpor and starvation resistance.

Fig. 3

a–h Effect of Gm11437 IKO and famsin on torpor evaluated by Tb (a), torpor frequency (number of torpor bouts, b), time for Tb < 35 °C (c), torpor entry time (d), minimum Tb (e), locomotor activity (f), relative total locomotor activity (g) and starvation resistance (h) of fasted 8-week-old male mice. Failure of starvation resistance was judged as Tb < 28 °C following a quick decrease in Tb below the environmental temperature. 400 μg/kg famsin was intraperitoneally injected after 4 h fasting. The gray and white backgrounds (a, f) indicate 12-h periods of darkness and light, respectively. Data are shown as means ± SEM. Comparison of different groups was carried out using one-way ANOVA followed by Tukey’s test (b–e, g) or log-rank test (h). *P < 0.05, **P < 0.01. NS no statistical significance. n = 7 mice. i–p Effect of adenoviral-expressed WT Gm11437 or Gm11437/AA on torpor evaluated by plasma famsin level (i), Tb (j), torpor frequency (k), time for Tb < 35 °C (l), torpor entry time (m), locomotor activity (n), relative total locomotor activity (o) and starvation resistance (p) of fasted 8-week-old male mice. Failure of starvation resistance was judged as Tb < 28 °C following a quick decrease in Tb below the environmental temperature. The gray and white backgrounds (j, n) indicate 12-h periods of darkness and light, respectively. Data are shown as means ± SEM. Comparison of different groups was carried out using one-way ANOVA followed by Tukey’s test (i, k–m, o) or log-rank test (p). *P < 0.05, **P < 0.01, ***P < 0.001. n = 7 mice.