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. 2023 Mar 31;14:1800. doi: 10.1038/s41467-023-36808-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A Surgical schematic and experimental timeline for LHb_5HT2c and BNST_5HT2c GRAB-5HT fiber photometry experiments in DiD-exposed mice. B Average alcohol consumption in DiD, p_2h = 0.0532 (Females n = 8 mice, Males n = 12 mice). C Cumulative alcohol intake in DiD, p = 0.2897 (Females n = 8 mice, Males n = 12 mice). D Average alcohol preference in DiD p_4h = 0.0039 (Females n = 8 mice, Males n = 12 mice). E Peri-event plot of LHb_5HT2c GRAB-5HT activity during the first interaction with a novel social target, females, (water n = 6 mice/1 trial, DiD n = 8 mice/1 trial). F Average z-score of LHb_5HT2c GRAB-5HT signal for 0–5 s post interaction, females, p = 0.0699 (water n = 6 mice/1 trial, DiD n = 8 mice/1 trial). G Peri-event plot of LHb_5HT2c GRAB-5HT activity during the first interaction with a novel social target, males (water n = 9 mice/1 trial, DiD n = 10 mice/1 trial). H Average z-score of LHb_5HT2c GRAB-5HT signal for 0–5 s post interaction, males (water n = 9 mice/1 trial, DiD n = 10 mice/1 trial). I Peri-event plot of BNST_5HT2c GRAB-5HT activity during the first interaction with a novel social target, females (water n = 8 mice/1 trial, DiD n = 7 mice/1 trial). J Average z-score of BNST_5HT2c GRAB-5HT signal for 0–5 s post interaction, females, p = 0.0008 (water n = 8 mice/1 trial, DiD n = 7 mice/1 trial). K Peri-event plot of BNST_5HT2c GRAB-5HT activity during the first interaction with a novel social target, males (water n = 11 mice/1 trial, DiD n = 12 mice/1 trial). L Average z-score of BNST_5HT2c GRAB-5HT signal for 0–5 s post interaction, males (water n = 11 mice/1 trial, DiD n = 12 mice/1 trial). M Peri-event plot of LHb_5HT2c GRAB-5HT activity during the acoustic startle test, females (water n = 6 mice/10 trials, DiD n = 8 mice/10 trials). N Peak z-score of LHb_5HT2c GRAB-5HT signal for 0–1 s post acoustic startle stimulus, females (water n = 6 mice/10 trials, DiD n = 8 mice/10 trials). O Peri-event plot of LHb_5HT2c GRAB-5HT activity during the acoustic startle test, males (water n = 9 mice/10 trials, DiD n = 10 mice/10 trials). P Average z-score of LHb_5HT2c GRAB-5HT signal for 0–5 s post acoustic startle stimulus, males (water n = 9 mice/10 trials, DiD n = 10 mice/10 trials). Q Peri-event plot of BNST_5HT2c GRAB-5HT activity during the acoustic startle test, females (water n = 8 mice/10 trials, DiD n = 8 mice/10 trials). R Average z-score of BNST_5HT2c GRAB-5HT signal for 0–5 s post acoustic startle stimulus, females (water n = 8 mice/10 trials, DiD n = 8 mice/10 trials). S Peri-event plot of BNST_5HT2c GRAB-5HT activity during the acoustic startle test, males (water n = 11 mice/10 trials, DiD n = 12 mice/10 trials). T Average z-score of BNST_5HT2c GRAB-5HT signal for 0–5 s post acoustic startle stimulus (water n = 11 mice/10 trials, DiD n = 12 mice/10 trials). Unless otherwise stated, statistical comparisons were performed using two-way Student’s unpaired t tests. All data represented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.0001. Source data are provided as a Source Data file. Created with Biorender.com.