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. 2023 Mar 31;13:106. doi: 10.1038/s41398-023-02399-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Adult ECon and EKyn offspring were treated with vehicle or PF-04859989 (30 mg/kg) at Zeitgeber time (ZT) 0. A 1-h bins of REM duration in male and female ECon (three-way ANOVA: treatment effect F_{(1, 13)} = 10.00, P < 0.01; Two-way ANOVA: Male Treatment effect F_{(1, 7)} = 8.938, P < 0.05). B 1-h bins of REM duration in male and female EKyn (three-way ANOVA: Treatment effect F_{(1, 14)} = 11.76, P < 0.01; two-way ANOVA: male treatment effect F_{(1, 7)} = 7.211, P < 0.05). C 6-h bins of REM duration in ECon, sexes combined (Treatment effect F_{(1, 14)} = 10.22, P < 0.01). D 6-h bins of REM duration in EKyn, sexes combined (Treatment effect F_{(1, 15)} = 11.15, P < 0.01). E 1-h bins of NREM duration in male and female ECon (Three-way ANOVA: treatment effect F_{(1, 13)} = 6.135, P < 0.05, treatment × sex × ZT interaction F_{(23, 281)} = 2.005, P < 0.01; two-way ANOVA: male treatment effect F_{(1, 7)} = 6.976, P < 0.05, female treatment × ZT interaction F_{(23, 120)} = 2.088, P < 0.01). F 1-h bins of NREM duration in male and female EKyn (three-way ANOVA: treatment effect F_{(1, 14)}= 8.530, P < 0.05, treatment × ZT interaction F_{(23, 310)} = 1.850, P < 0.05, treatment × sex × ZT interaction F_{(23, 310)} = 1.780, P < 0.05; two-way ANOVA: male treatment effect F_{(1, 7)} = 6.510, P < 0.05, female treatment × ZT interaction F_{(23, 149)}= 2.218, P < 0.01). G 6-h bins of NREM duration in ECon, sexes combined (treatment effect F_{(1, 14)}= 10.74, P < 0.01). H 6-h bins of NREM duration in EKyn, sexes combined (treatment effect F_{(1, 15)} = 7.915, P < 0.05). I 1-h bins of wake duration in male and female ECon (three-way ANOVA: treatment effect F_{(1, 13)} = 7.459, P < 0.05, treatment × ZT interaction F_{(23, 281)} = 1.720, P < 0.05, treatment × sex × ZT interaction F_{(23, 281)} = 2.011, P < 0.01; two-way ANOVA: male treatment effect F_{(1, 7)} = 6.445, P < 0.05, female treatment × ZT interaction F_{(23, 120)} = 2.114, P < 0.01). J 1-h bins of wake duration in male and female EKyn (three-way ANOVA: treatment effect F_{(1, 14)} = 12.07, P < 0.01, treatment × ZT interaction F_{(23, 310)} = 1.755, P < 0.05, treatment × sex × ZT interaction F_{(23, 310)}= 1.875, P < 0.01; two-way ANOVA: male treatment effect F_{(1, 7)} = 12.30, P < 0.01, female treatment × ZT interaction F_{(23, 149)} = 2.235, P < 0.01). K 6-h bins of wake duration in ECon, sexes combined (treatment effect F_{(1, 14)} = 11.98, P < 0.01). L 6-h bins of wake duration in EKyn, sexes combined (treatment effect F_{(1, 15)} = 11.05, P < 0.01). Data are mean ± SEM. Percent change from vehicle treatment calculations are shown by arrows. Three-way RM ANOVA: ^#P < 0.05, ^##P < 0.01. two-way RM ANOVA: ^{^}P < 0.05, ^{^^}P < 0.01 with Fisher’s LSD post hoc test: *P < 0.05, **P < 0.01, ***P < 0.001. N = 12–16 per group.