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. 2023 Mar 31;13:106. doi: 10.1038/s41398-023-02399-1

Fig. 3. Reduction in KYNA levels at the beginning of light phase enhances NREM delta spectral power in ECon and EKyn offspring.

Fig. 3

Adult ECon and EKyn offspring were treated with vehicle or PF-04859989 (30 mg/kg) at Zeitgeber time (ZT) 0. A Male ECon during light phase (treatment × frequency interaction F(7, 49) = 2.892, P < 0.05). B Male ECon during dark phase (Treatment effect F(1, 7) = 6.678, P < 0.05). C Female ECon during light phase (treatment × frequency interaction F(7, 42) = 2.897, P < 0.05). D Female ECon during dark phase. E Male EKyn during light phase (Treatment effect F(1, 7) = 9.155, P < 0.05). F Male EKyn during dark phase. G Female EKyn during light phase. H Female EKyn during dark phase. Data are mean ± SEM. Two-way RM ANOVA: ^P < 0.05 with Fisher’s LSD post hoc test: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. N = 7–8 per group.