Table 1.
Major epi/pandemics over time.
| Name | Time period | Type / Pre-human host | Death toll |
|---|---|---|---|
| Antonine Plague | 165-180 | Believed to be either smallpox or measles | 5M |
| Japanese smallpox epidemic | 735-737 | Variola major virus | 1M |
| Plague of Justinian | 541-542 | Yersinia pestis bacteria / Rats, fleas | 30-50M |
| Black Death | 1347-1351 | Yersinia pestis bacteria / Rats, fleas | 200M |
| New World Smallpox Outbreaks | >1520 | Variola major virus (eradicated in 1980) | 56M |
| Great Plague of London | 1665 | Yersinia pestis bacteria / Rats, fleas | 100,000 |
| Italian plague | 1629-1631 | Yersinia pestis bacteria / Rats, fleas | 1M |
| Cholera Pandemics 1-6 | 1817-1923 | V. cholerae bacteria | 1M+ |
| Third Plague | 1885 | Yersinia pestis bacteria / Rats, fleas | 12M (China and India) |
| Yellow Fever | Late 1800s | Virus / Mosquitoes | 100,000-150,000 (U.S.) |
| Russian Flu | 1889-1890 | Believed to be H2N2 (avian origin) | 1M |
| Spanish Flu | 1918-1919 | H1N1 virus / Pigs | 40-50M |
| Asian Flu | 1957-1958 | H2N2 virus | 1.1M |
| Hong Kong Flu | 1968-1970 | H3N2 virus | 1M |
| HIV/AIDS | >1981 | Virus / Chimpanzees | 25-35M |
| Swine Flu | 2009-2010 | H1N1 virus / Pigs | 200,000 |
| SARS | 2002-2003 | Coronavirus / Bats, Civets | 770 |
| Ebola | >2014 recurring |
Ebolavirus / Wild animals | 11,000 |
| MERS | >2015 recurring | Coronavirus / Bats, camels | 850 |
| COVID-19 | >2019 | Coronavirus – Unknown possiblyy pangolins) | 6.3M (Johns Hopkins University estimate, as of July 8, 2022) |
Source: Adapted from LePan.3
Abbreviations: COVID: coronavirus disease; HIV/AIDS Human Immunodeficiency Virus/ Acquired Immunodeficiency Syndrome; MERS: Middle East Respiratory Syndrome; SARS: severe acute respiratory syndrome.