Figure 3.

Relationships between $\mathbf{p}\mathbf{T}\mathbf{a}{\mathbf{u}}_{\mathbf{217}}$ and longitudinal cognition. (A) Global cognition (PACC-3) as a function of age and baseline $\mathrm{pTa}{\mathrm{u}}_{217}$ level. Individual observations from a single participant are connected by grey line segments. Superimposed coloured lines reflect estimated simple main effects of age from the mixed effects model reported in Table 3, Model 2 (t(493.43)=−7.58, P = 0.00000000000017). Low, medium and high $\mathrm{pTa}{\mathrm{u}}_{217}$ values reflect the 10th, 50th and 90th sample percentiles. (B–D) Repeated measures correlations (r; df = 46) between global cognition (PACC-3) and $\mathrm{pTa}{\mathrm{u}}_{217}$ with lags of 0 (B; P = 0.37), 1 (C; P = 0.000059) and 2 (D; P = 0.00000020) visits between biomarker and cognitive test. The steeper slope in the rightmost panel suggests a stronger negative relationship between earlier $\mathrm{pTa}{\mathrm{u}}_{217}$ and downstream PACC-3. PACC-3: three-test preclinical Alzheimer’s cognitive composite; $\mathrm{pTa}{\mathrm{u}}_{217}$ = phosphorylated tau 217.