Table 3.

The results of linear mixed effect models of PACC-3 as a function of (i) covariates only (sex, education, baseline literacy and age), (ii) covariates plus baseline $\mathbf{p}\mathbf{T}\mathbf{a}{\mathbf{u}}_{\mathbf{217}}$ and its interaction with age. In both models, age was modelled as a second-degree polynomial. Models included a per-participant random intercept

	Base model			With pTau217
Predictors	Estimates	CI	P	Estimates	CI	P
Intercept	−3.71	−5.43–−1.99	<0.001	−4.14	−5.83–−2.44	<0.001
Sex (male)	−0.41	−0.69–−0.13	0.004	−0.49	−0.77–−0.22	0.001
Education (years)	0.09	0.01–0.16	0.024	0.10	0.03–0.17	0.007
Baseline literacy	0.02	0.00–0.04	0.026	0.02	0.00–0.04	0.015
Practice	0.12	0.05–0.19	0.001	0.14	0.07–0.21	<0.001
Age (centred), linear	−0.07	−0.10–−0.05	<0.001	−0.09	−0.11–−0.06	<0.001
Age (centred), quadratic	−0.00	−0.00–−0.00	0.001	−0.00	−0.00–−0.00	0.015
Baseline pTau217				−0.07	−0.25–0.11	0.466
Baseline pTau217×age [centred], linear				−0.07	−0.09–−0.06	<0.001
Baseline pTau217 × Age (centred), quadratic				−0.00	−0.00–0.00	0.666
Random effects
σ2	0.24			0.20
τ00	0.64 Reggieid			0.63 Reggieid
ICC	0.73			0.76
N	165 Reggieid			165 Reggieid
Observations	509			509
Marginal R2/conditional R2	0.237/0.793			0.330/0.840

ICC = intraclass correlation; $\mathrm{pTa}{\mathrm{u}}_{217}$ = phosphorylated tau 217.

Bold text denotes statistical significance.