Figure 8.

Published aging signatures are influenced by gene length-dependent transcriptional decay

Down-regulated genes are longer than up-regulated genes in two published aging transcriptomic signatures. The length of the genes from two independent aging signatures, murine (A) and human (B), are shown as two overlapped histograms and separate boxplots. The number of down-and up-regulated genes in each signature are shown as n_d and n_u, respectively. The gene length is significantly different between the two categories according to the Mann-Whitney test (p values shown in the figure). Whiskers extend to the furthest datapoint within the 1.5∗IR.