FIGURE 3.

Improvement of microbicidal activity by elexacaftor/tezacaftor/ivacaftor. a) Pseudomonas aeruginosa survival in peripheral blood mononuclear cells isolated from healthy donors (HD) and people with cystic fibrosis before (Pre) and after 1 (M1) and 6 (M6) months of therapy. CFU recovered at the end of infection (t₀) and 60 min after infection (t₆₀). The average slopes are reported above the t₀–t₆₀ connecting lines. Slopes were calculated with the linear regression model. Wilcoxon test. b) Killing activity at t₆₀. Scattered dot plot with mean±sem. Kruskal–Wallis test with Dunn's multiple comparison. c) Longitudinal analysis of data. Friedman test with Dunn's multiple comparison. *: p<0.05; **: p<0.01; ***: p<0.001; ****: p<0.0001.