Skip to main content
. 2023 Apr 3;61(4):2200725. doi: 10.1183/13993003.00725-2022

FIGURE 5.

FIGURE 5

Elexacaftor/tezacaftor/ivacaftor reduces the exuberant oxidative burst and improves microbicidal activity. a) Superoxide anion O−2 production by infected peripheral blood mononuclear cells (PBMCs) as detected by the luminol assay. i) Representative kinetics of O−2 production (relative luminescence units (RLU)). ii) Quantitative analysis of O−2 produced by the indicated samples (area under the curve (AUC)). Scattered dot plot with mean±sem. Kruskal–Wallis test with Dunn's multiple comparison. iii) Longitudinal analysis of data. Friedman test with Dunn's multiple comparison. b) CFU recovered from untreated or diphenyleneiodonium (DPI)-treated PBMCs. i) CFU recovered from PAO1-infected cells. Wilcoxon test. ii) Fold increase of CFU in DPI-treated cells with respect to untreated cells. Scattered dot plot with mean±sem. Kruskal–Wallis test with Dunn's multiple comparison. iii) Longitudinal analysis of data. Friedman test with Dunn's multiple comparison. HD: healthy donors; Pre: before therapy; M1: month 1; M6: month 6. *: p<0.05; **: 0.01; ***: p<0.001.