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. 2023 Apr 3;61(4):2200725. doi: 10.1183/13993003.00725-2022

FIGURE 6.

FIGURE 6

Elexacaftor/tezacaftor/ivacaftor rapidly reduces the high level of NADPH oxidase 2 (NOX2) activation. Analysis of the p47phox and phosphorylated p47phox (p-p47phox) NOX2 subunits in monocytes from healthy donors (HD; n=6) and people with cystic fibrosis before (Pre; n=6) and after 1 month of therapy (M1; n=6). a) Representative blots of cell lysates from non-infected and PAO1-infected monocytes. b, c) Quantitative analysis of b) p47phox and c) p-p47phox. Data are presented as mean±sem. Brown–Forsythe ANOVA test with t-test for multiple comparison. GAPDH: glyceraldehyde 3-phosphate dehydrogenase (loading control). *: p<0.05; **: p<0.01; ***: p<0.001; ****: p<0.0001.