Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 1;42(3):112173. doi: 10.1016/j.celrep.2023.112173

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

SLM2 directly regulates alternative splicing of mRNAs encoding synaptic proteins

(A) Log2 fold change splicing index (FC SI) and −log10 p values of splicing patterns comparing WT and Slm2 mutants. Significantly regulated exons are marked in color (fold change ≥ 2, p ≤ 0.01).

(B and C) Sequencing tracks for WT and mutant (Δ) RiboTrap samples for hippocampal Grik4, CamK2, and SST cells and eCLIP analysis in whole brain and hippocampus for de-regulated exons of Nrxn2 and Nrxn3. SLM2 binding events in downstream introns align with UWAA motifs. Coordinates: Nrxn2 chr19:6,509,778–6,517,248; Nrxn3 chr12:90,168,920–90,204,818.