Table 2.

Linear Mixed-Effects Models Examining Influence of SCD+ Status on Cognition Over Time

	Global cognition	Episodic memory	Semantic memory	Perceptual speed	Visuospatial abilities	Working memory
Age	β = −0.01	β = −0.02	β = −0.02	β = −0.03	β = −0.007	β = −0.004
	SE = 0.001	SE = 0.001	SE = 0.001	SE = 0.001	SE = 0.001	SE = 0.002
	t = −13.05, p < .001*	t = −13.37, p < .001*	t = −12.55, p < .001*	t = −18.92, p < .001*	t = −5.22, p < .001*	t = −2.85, p < .001*
Time From Baseline	β = −0.04	β = −0.03	β = −0.05	β = −0.07	β = −0.02	β = −0.02
	SE = 0.002	SE = 0.002	SE = 0.002	SE = 0.002	SE = 0.001	SE = 0.001
	t = −19.93, p < .001*	t = −11.72, p < .001*	t = −21.43, p < .001*	t = −34.60, p < .001*	t = −11.81, p < .001*	t = −13.04, p < .001*
SCD Diagnosis	β = −0.04	β = −0.06	β = −0.06	β = −0.09	β = 0.03	β = 0.02
	SE = 0.02	SE = 0.02	SE = 0.02	SE = 0.03	SE = 0.02	SE = 0.03
	t = −2.36, p = .018*	t = −3.27, p = .001*	t = −2.28, p = .022*	t = −3.19, p = .001*	t = −1.11, p = .27	t = 0.64, p = .52
SCD: Time From Baseline	β = −0.03	β = −0.03	β = −0.03	β = −0.01	β = −0.01	β = −0.02
	SE = 0.003	SE = 0.005	SE = 0.004	SE = 0.004	SE = 0.003	SE = 0.003
	t = −7.19, p < .001*	t = −6.67, p < .001*	t = −6.96, p < .001*	t = −3.53, p < .001*	t = −3.74, p < .001*	t = −4.79, p < .001*
Male Sex	β = −0.09	β = −0.17	β = −0.07	β = −0.20	β = 0.26	β = −0.03
	SE = 0.02	SE = 0.02	SE = 0.03	SE = 0.03	SE = 0.02	SE = 0.03
	t = −4.96, p < .001*	t = −9.03, p < .001*	t = −2.96, p = .003*	t = −7.11, p < .001*	t = 10.90, p < .001*	t = −1.04, p = .30
Education	β = 0.06	β = 0.05	β = 0.05	β = 0.07	β = 0.06	β = 0.06
	SE = 0.002	SE = 0.002	SE = 0.002	SE = 0.003	SE = 0.003	SE = 0.003
	t = 29.51, p < .001*	t = 22.15, p < .001*	t = 19.01, p <. 001*	t = 21.74, p < .001*	t = 22.29, p < .001*	t = 21.74, p < .001*

Notes: SCD = subjective cognitive decline.

*Represents the values that were statistically significant. All results remained significant after correction for multiple comparisons using false discovery rate.