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Observed and fitted (A) concentration–time profiles of mRNA-3927 in mice, rats, and monkeys, and (B) PCC protein–time profile after 1 mg/kg IV bolus dose of hPCCA+hPCCB mRNA in PCC-deficient mice. Black lines indicate population predicted, blue lines indicate individual predicted, and closed circles indicate observations. DV, dependent variable (plasma concentration); IV, intravenous; mRNA, messenger RNA; PCC, propionyl-CoA carboxylase.
