Table 1.
The Clinical Characteristic and Laboratory Tests in MNP and Non-MNP
| Overall (n=282) | Non-MNP (n=188) | MNP (n=94) | P | |
|---|---|---|---|---|
| General information | ||||
| Age (mean (SD)), y | 5.11 (3.96) | 5.28 (4.04) | 4.77 (3.79) | 0.302 |
| Weight (mean (SD)), kg | 17.28 (10.18) | 17.57 (9.59) | 16.69 (11.29) | 0.493 |
| Sex (boy/girl), n | 125/157 | 85/103 | 40/54 | 0.767 |
| Clinical features | ||||
| Cough, n (%) | 255 (90.4) | 175 (93.1) | 80 (85.1) | 0.053 |
| Hemoptysis, n (%) | 7 (2.5) | 5 (2.7) | 2 (2.1) | 1 |
| Chest pain, n (%) | 36 (12.8) | 25 (13.3) | 11 (11.7) | 0.85 |
| Wheezing, n (%) | 40 (14.2) | 27 (14.4) | 13 (13.8) | 1 |
| Shortness of breath, n (%) | 50 (17.7) | 28 (14.9) | 22 (23.4) | 0.11 |
| Rales, n (%) | 76 (27.0) | 44 (23.4) | 32 (34.0) | 0.079 |
| Duration of fever (median [IQR]), d | 10.00 [6.00, 15.00] | 10.00 [5.00, 15.00] | 10.00 [7.00, 15.00] | 0.868 |
| Peak body temperature (median [IQR]), °C | 39.50 [39.00, 40.00] | 39.50 [39.00, 40.00] | 39.50 [39.00, 40.00] | 0.65 |
| Haematogenous spread | 11 (3.9) | 1 (0.5) | 10 (10.6) | <0.001 |
| Radiological features | ||||
| Lobar consolidation, n (%) | 86 (30.5) | 55 (29.3) | 31 (33.0) | 0.615 |
| Pleural effusion, n (%) | 118 (41.8) | 74 (39.4) | 44 (46.8) | 0.286 |
| Atelectasis, n (%) | 58 (20.6) | 39 (20.7) | 19 (20.2) | 1.000 |
| Complications | ||||
| Digestive system, n (%) | 82 (29.1) | 47 (25.0) | 35 (37.2) | 0.046 |
| Nervous system, n (%) | 8 (2.8) | 5 (2.7) | 3 (3.2) | 1 |
| Urinary system, n (%) | 2 (0.7) | 1 (0.5) | 1 (1.1) | 1 |
| Circulatory system, n (%) | 27 (9.6) | 17 (9.0) | 10 (10.6) | 0.83 |
| Endocrine system, n (%) | 9 (3.2) | 3 (1.6) | 6 (6.4) | 0.072 |
| Blood system, n (%) | 60 (21.3) | 36 (19.1) | 24 (25.5) | 0.28 |
| Laboratory values | ||||
| WBC (median [IQR]),109/L | 12.66 [9.28, 17.09] | 10.93 [8.42, 14.39] | 17.01 [13.02, 22.56] | <0.001 |
| Hb (median [IQR]), g/L | 110.38 [98.00, 122.75] | 115.00 [102.00, 124.25] | 102.00 [92.00, 115.75] | <0.001 |
| PLT (median [IQR]),109/L | 453.00 [320.00, 562.75] | 445.50 [323.75, 550.75] | 459.00 [311.25, 606.00] | 0.585 |
| N% (median [IQR]) | 62.05 [51.52, 74.97] | 60.85 [49.17, 72.30] | 68.50 [57.45, 78.18] | 0.001 |
| L% (median [IQR]) | 26.40 [16.95, 38.08] | 28.90 [18.88, 39.82] | 21.70 [12.75, 31.84] | <0.001 |
| CRP (median [IQR]), mg/L | 52.98 [14.07, 99.03] | 30.20 [7.40, 75.23] | 74.44 [47.61, 176.21] | <0.001 |
| PCT (median [IQR]), ng/mL | 6.60 [0.41, 6.60] | 3.96 [0.30, 6.60] | 6.60 [1.19, 6.60] | 0.001 |
| AST (median [IQR]), U/L | 18.00 [12.00, 35.30] | 16.50 [12.00, 34.00] | 23.50 [14.00, 38.75] | 0.005 |
| ALT (median [IQR]), U/L | 32.00 [25.00, 49.00] | 30.00 [23.75, 46.00] | 39.00 [27.25, 53.00] | 0.01 |
| LDH (median [IQR]), U/L | 322.50 [251.25, 395.50] | 285.50 [233.75, 363.70] | 393.00 [346.00, 500.50] | <0.001 |
| Alb (median [IQR]), g/L | 33.30 [29.22, 36.95] | 33.55 [30.37, 38.00] | 31.85 [27.62, 34.25] | <0.001 |
| PT (median [IQR]), s | 13.00 [11.90, 13.60] | 13.00 [11.90, 13.60] | 12.75 [12.00, 13.57] | 0.555 |
| APTT (median [IQR]), s | 32.20 [26.83, 36.25] | 33.25 [27.67, 37.10] | 32.20 [25.90, 35.40] | 0.023 |
| FG (median [IQR]), g/L | 4.53 [3.39, 5.43] | 4.53 [3.35, 5.46] | 4.53 [3.52, 5.29] | 0.494 |
| MP infection, (%) | 62 (22.0) | 46 (24.5) | 16 (17.0) | 0.204 |
| Viral infection, n (%) | 98 (34.8) | 68 (36.2) | 30 (31.9) | 0.565 |
| Bacterial infections, n (%) | 46 (16.3) | 32 (17.0) | 14 (14.9) | 0.776 |
| Co-infection, n (%) | 53 (18.8) | 42 (22.3) | 11 (11.7) | 0.046 |
| Treatment | ||||
| Glucocorticoid, n (%) | 70 (24.8) | 42 (22.3) | 28 (29.8) | 0.223 |
| IVIG, n (%) | 15 (5.3) | 8 (4.3) | 7 (7.4) | 0.398 |
| ICU admission, n (%) | 24 (8.5) | 13 (6.9) | 11 (11.7) | 0.258 |
| Thoracic close drainage, n (%) | 28 (9.9) | 10 (5.3) | 18 (19.1) | 0.001 |
| Surgery, n (%) | 85 (30.1) | 48 (25.5) | 37 (39.4) | 0.025 |
| Duration of hospitalization (mean (SD)), d | 19.78 (12.26) | 18.21 (11.88) | 22.91 (12.46) | 0.002 |
| Hospitalization expenses (median [IQR]), $ | 3303.00 [1718.00, 4640.00] | 3005.00 [1517.00, 4276.00] | 3784.00 [2342.00, 6250.00] | 0.001 |
Abbreviations: MNP, massive necrotizing pneumonia; SD, standard deviation; IQR, interquartile range; WBC, white blood cell; Hb, hemoglobin; PLT, platelet; N%, percentage of neutrophils; L%, percentage of lymphocytes; CRP, C -reactive protein; PCT, procalcitonin; ALT, alanine aminotransferase; AST, alanine aminotransferase; Alb, albumin; LDH, lactate dehydrogenase; PT, prothrombin time; APTT, activated partial thromboplastin time; FG, Fibrinogen; MP, Fibrinogen; IVIG, intravenous immune globulin; ICU, intensive care unit.