Table 2:
Common SNP associations (p<5.0×10−7) in the MVP ADRD+proxy dementia+ADGC AD meta-analysis
| SNP | Chr | Pos | A1/A2 | Nearest Gene(s) | ADRD OR | ADRD P | Proxy P | MVP P | ADGC P | All P | Dir | MAF | r2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs116329346 | 2 | 38743886 | A/G | AC016995.3 | 1.66 | 7.93E-04 | 9.13E-05 | 2.57E-07 | 6.97E-01 | 4.46E-06 | ++− | 0.01 | 0.77 |
| rs58443395 | 2 | 53482134 | A/G | AC010967.2-SCARNA16 | 1.13 | 1.35E-03 | 1.14E-03 | 5.39E-06 | 2.99E-02 | 4.75E-07 | −−− | 0.12 | 0.94 |
| rs10197243 | 2 | 55052493 | T/C | EML6 | 1.09 | 1.88E-02 | 4.79E-06 | 4.96E-07 | 1.60E-01 | 2.27E-07 | +++ | 0.15 | 0.89 |
| rs567572378 | 3 | 19633465 | A/C | KCNH8-EFHB | 1.89 | 2.21E-04 | 2.63E-04 | 2.42E-07 | NA | 2.42E-07 | ++? | 0.01 | 0.75 |
| rs11919682 | 3 | 78770102 | C/G | ROBO1 | 0.86 | 6.70E-07 | 1.23E-03 | 1.63E-08 | NA | 1.63E-08 | −−? | 0.27 | 0.85 |
| rs192764155 | 4 | 59794471 | A/G | RP11–506N2.1 | 1.27 | 4.86E-03 | 7.43E-06 | 1.51E-07 | NA | 1.51E-07 | −−? | 0.02 | 0.88 |
| rs148433063 | 4 | 59886649 | T/C | RP11–340A13.2 | 1.28 | 3.20E-03 | 5.07E-07 | 8.65E-09 | 9.04E-01 | 1.54E-07 | −−+ | 0.02 | 0.92 |
| rs28377689 | 4 | 80967671 | T/G | ANTXR2 | 1.10 | 1.63E-03 | 8.24E-05 | 4.59E-07 | 4.22E-01 | 1.53E-05 | −−+ | 0.27 | 0.84 |
| rs74852218 | 5 | 25701222 | A/G | RNU6–374P | 1.44 | 4.44E-04 | 5.01E-05 | 8.20E-08 | 7.53E-01 | 4.26E-07 | +++ | 0.01 | 0.86 |
| rs114681435 | 5 | 38361541 | T/G | EGFLAM | 1.37 | 2.12E-04 | 1.16E-03 | 1.17E-06 | 1.16E-01 | 3.64E-07 | −−− | 0.03 | 0.72 |
| rs2234253 | 6 | 41129105 | T/G | TREM2 | 1.20 | 6.05E-07 | 9.03E-03 | 2.23E-07 | NA | 2.23E-07 | ++? | 0.13 | 1.00 |
| rs73427293 | 6 | 41136611 | A/T | TREM2-TREML2 | 1.19 | 2.70E-06 | 5.33E-03 | 2.95E-07 | 1.89E-03 | 2.95E-09 | −−− | 0.13 | 0.98 |
| rs16894668 | 6 | 41388910 | T/C | AL136967.1-RP11–328M4.2 | 1.39 | 1.05E-05 | 2.51E-03 | 2.91E-07 | 9.18E-01 | 2.89E-06 | ++− | 0.02 | 0.99 |
| rs7738720 | 6 | 47395399 | T/C | RP11–157D6.1-CD2AP | 0.83 | 1.35E-04 | 9.62E-05 | 5.48E-08 | 5.51E-03 | 1.14E-09 | −−− | 0.10 | 0.76 |
| rs4607615 | 8 | 10279626 | C/G | MSRA | 1.13 | 4.76E-05 | 3.06E-03 | 1.13E-06 | 2.11E-02 | 7.37E-08 | −−− | 0.24 | 0.95 |
| rs73581622 | 8 | 31258426 | A/G | RP11–566H8.3-RP11–566H8.1 | 1.58 | 2.24E-03 | 3.73E-05 | 2.94E-07 | 6.98E-01 | 4.98E-06 | ++− | 0.01 | 0.86 |
| rs112395375 | 8 | 105698769 | A/G | RP11–127H5.1 | 0.50 | 5.94E-07 | 5.91E-03 | 1.22E-07 | 4.86E-01 | 2.73E-07 | +++ | 0.01 | 0.80 |
| rs76427927 | 8 | 116123287 | A/C | RP11–192P9.1-TRPS1 | 1.10 | 8.30E-02 | 1.76E-05 | 9.81E-06 | 6.23E-03 | 2.76E-07 | −−− | 0.06 | 0.92 |
| rs509334 | 11 | 121277918 | A/G | BRP11–142I2.1-SORL1 | 0.85 | 3.90E-06 | 2.73E-03 | 1.59E-07 | 8.33E-01 | 9.33E-07 | +++ | 0.20 | 0.79 |
| rs145008711 | 15 | 68726103 | A/T | ITGA11 | 1.58 | 3.03E-03 | 4.67E-05 | 4.94E-07 | 8.97E-01 | 4.75E-06 | −−+ | 0.01 | 0.76 |
| rs116620371 | 18 | 34179992 | A/G | FHOD3 | 0.65 | 3.54E-03 | 5.71E-06 | 8.39E-08 | 6.07E-01 | 2.26E-06 | −−+ | 0.01 | 0.92 |
| rs73505251 | 19 | 1068095 | A/T | ABCA7 | 1.13 | 8.14E-04 | 7.03E-05 | 2.03E-07 | 1.23E-04 | 3.26E-10 | +++ | 0.13 | 0.98 |
| rs429358 | 19 | 45411941 | T/C | APOE | 1.58 | 2.90E-58 | 2.56E-47 | 2.48E-101 | 2.59E-60 | 6.09E-150 | −−− | 0.22 | 0.99 |