Skip to main content
. Author manuscript; available in PMC: 2023 Apr 2.
Published in final edited form as: Ann Rheum Dis. 2022 Mar 25;81(8):1143–1150. doi: 10.1136/annrheumdis-2022-222168

Table 4.

Autoantibodies detected in patients with an ANA that was within the normal range on IFA1, IFA2, ELISA, either alone, on two or all three assay at enrolment and year 5*

ELISA IFA1 IFA2 IFA1&ELISA ELISA and IFA2 IFA1&IFA2 All three assays
% Autoantibodies Enrolment (N=27) Year 5 (N=70) Enrolment (n=31) Year 5 (n=39) Enrolment (N=14) Year 5 (N=9) Enrolment (N=8) Year 5 (N=20) Enrolment (N=3) Year 5 (N=4) Enrolment (N=8) Year 5 (N=6) Enrolment (N=3) Year 5 (N=3)
None detected 44.4 45.7 38.7 53.8 42.9 44.4 62.5 65.0 66.7 50.0 50.0 50.0 66.7 66.7
dsDNA1 7.7 5.7 6.7 5.1 0.0 11.1 0.0 0.0 0.0 0.0 0.0 16.7 0.0 0.0
Ribosomal P 3.7 11.4 6.5 10.3 7.1 11.1 0.0 10.0 0.0 25.0 0.0 16.7 0.0 33.3
Ro52/TRIM21 11.1 21.4 22.6 20.5 21.4 11.1 0.0 20.0 0.0 25.0 0.0 0.0 0.0 0.0
SSA/Ro60 7.4 12.9 25.8 10.3 21.4 11.1 0.0 5.0 0.0 0.0 12.5 0.0 0.0 0.0
SSB/La 7.4 7.1 0.0 5.1 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0
Sm 3.7 4.3 6.5 2.6 0.0 11.1 0.0 0.0 0.0 25.0 0.0 0.0 0.0 0.0
U1RNP 3.7 7.1 0.0 5.1 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0
Histones 0.0 10.0 0.0 2.6 7.1 11.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
*

Patients who were within the normal range for ANA at enrolment are not necessarily the same patients at year 5 and vice versa.

Abbreviations: ANA, anti-nuclear antibodies; β2GP1, β2-glycoprotein-1; dsDNA, double-stranded DNA; ELISA, enzyme-linked immunosorbent assay, IFA; indirect immunofluorescence assay; IgG/M, immunoglobulin G/immunoglobulin M; RNP, ribonucleoprotein; Sm, Smith; TRIM21, TRIpartite Motif protein (TRIM) 21.

1

dsDNA was measured at enrolment for only 26 patients on ELISA, 13 on IFA2, and 2 on both who tested within the normal range for ANA