Skip to main content
. Author manuscript; available in PMC: 2023 Apr 2.
Published in final edited form as: Cell Host Microbe. 2022 Jan 7;30(2):248–259.e6. doi: 10.1016/j.chom.2021.12.009

Figure 3. Neutralizing activities of vaccinee sera against RVPs bearing 17D/ES-504 domain-swapped E proteins.

Figure 3.

(A) Schematic of the 17D/ES-504 E protein chimeras. (B–C) Serum neutralizing titers for the three U.S. donors (see Figure 1A) at the indicated times post-vaccination against the indicated RVPs. Means±SEM, n=6–12 from 2–4 independent experiments. (D–E) Serum neutralizing titers for a U.S. vaccinee cohort (n=16 donors; see Figure 1E) against the indicated RVPs. n=6–12 from 2–4 independent experiments. Parental RVP17D and RVPES-504 controls are from Figure 1E. Groups in D–E were compared to WT by two-way ANOVA followed by Tukey’s correction for multiple comparisons. **, P<0.002. ****, P<0.0001. Only the significant comparisons are shown. In all panels, lines indicate group medians. LOD, limit of detection.