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. 2022 Nov 16;12(6):7616–7626. doi: 10.1002/cam4.5442

FIGURE 2.

FIGURE 2

CRC biomarker candidate proteins identified in cohort 1. Comparisons of the relative amount of each protein in plasma EVs in the two groups, namely, between Stage I and HC1 (A), Stage IV and HC2 (B), and Stage I and Stage IV (C), are shown as a heat map. Colors ranging from blue to red represent log 2 (fold change), and asterisks indicate significance in the MWW tests (*p‐value <0.05. **p‐value <0.003). The top 50 proteins in the feature importance score in the RF analysis, derived from two datasets, Stages I and IV (D) and Stages I, IV, and HC1 and 2 (E), are shown in green panels.