Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 4;12(6):7207–7221. doi: 10.1002/cam4.5511

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

The inhibitory pathway of DC function by other immune cells. BTLA: B‐and T‐lymphocyte attenuator; CTLA‐4: Cytotoxic T lymphocyte‐associated antigen‐4; DC: Dendritic cell; GITR: Glucocorticoid‐induced tumor necrosis factor receptor; IFN‐γ: Interferon γ; IL‐10: Interleukin 10; IL‐12: Interleukin 12; IL‐23: Interleukin 23; MDSC: Myeloid‐derived suppressor cells; NK cells: Natural killer cells; PD‐1: Programmed cell death‐1; pro‐MMP2: Precursor metalloproteinase 2; TGF‐β: Transforming growth factor‐β; Tim‐3: T cell immunoglobulin domain and mucin domain‐3; The inhibitory effect of myeloid‐derived suppressor cells (MDSCs), Tregs, and microglia/tumor associated macrophages (TAMs) on DCs will damage the function of DCs and promote tumor growth and reproduction.