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. Author manuscript; available in PMC: 2023 Apr 2.
Published in final edited form as: Pain. 2022 Apr 1;163(4):682–689. doi: 10.1097/j.pain.0000000000002401

Figure 3.

Figure 3.

Bodyweight and blood biomarkers in diabetic mice following an uncontrolled diabetes (A, C, E) or dietary intervention (B, D, E) paradigm. Diabetic mice fail to gain bodyweight (A), which is modestly rescued following administration of a ketogenic diet (B) (n=6–10). Diabetic mice fed a ketogenic diet develop nutritional ketosis yet remain below the threshold of life-threatening ketoacidosis (C and D) (8 mM β-HB; n=6–10). Diabetic mice exhibit robust increase in fasting blood glucose (E), which is significantly reduced following administration of a ketogenic diet (F) (n=6–10). (A-E) Mixed-models ANOVA with repeated measures and Tukey’s post hoc test; * p < 0.05 compared to chow-fed non-diabetic mice.