Figure 5.

Sensory behavior in diabetic mice following an uncontrolled diabetes (A, C) or dietary intervention (B, D) paradigm. Diabetes induces a sharp and lasting onset of mechanical allodynia (A), which is reversed within one week of administering a ketogenic diet (B) (n=6–10). Diabetic mice develop delayed responsiveness to radiant heat following 9 weeks of uncontrolled diabetes (C). Following administration of a ketogenic diet, thermal latency returns to normal (D) (n=6–10). (A-B) Mixed-models ANOVA with repeated measures and Tukey’s post hoc test; * p < 0.05 compared to chow-fed non-diabetic mice.