Table 4.

Differences in metabolite super pathways from bison meat finished on pasture (pasture) or in loose confinement on grain-based concentrates (pen)

Super pathway	Cluster size	P-values	FDR	Key compound	Altered metabolites	↑Pasture	↑Pen
Amino acid	162	< 0.001	< 0.001	S-methylmethionine	94	24	56
Lipid	138	< 0.001	< 0.001	5-dodecenoylcarnitine (C12:1)	83	43	33
Carbohydrate	44	< 0.001	< 0.001	Methyl glucopyranoside	29	2	22
Nucleotide	39	< 0.001	< 0.00	N1-methylinosine	24	5	12
Xenobiotics/Phytochemicals	27	< 0.001	0.001	4-Ethylphenylsulfate	16	10	5
Peptide	30	< 0.001	0.001	Phenylacetylglycine	17	8	6
Cofactors/Vitamins	28	< 0.001	0.001	Alpha-tocopherol	13	3	9
Energy	12	0.01	0.01	L-Isocitric acid	7	4	1

Analyzed using chemical similarity enrichment analysis software (ChemRICH https://chemrich.idsl.me/home)