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. 2023 Apr 1;15:57. doi: 10.1186/s13148-023-01472-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — NGB-OE suppresses tumor angiogenesis ability of CRC cells. A Heatmap of differentially expressed proteins in NGB-overexpressing or vector HCT116 cells. B Angiogenesis estimated by endothelial cell tube formation assay; statistical analysis of tube formation and branches is shown on the right used angiogenesis tool of image J, N = 3. CM means conditional medium. C Immunofluorescence: the effect of NGB on CD31 expression status in CRC cells. D The status of angiogenesis pathway detected by WB or WES. E Immunofluorescence: the effect of NGB on VEGFR2 expression in CRC cells. All experiments were performed in triplicate. *p < 0.05, **p < 0.01, ***p < 0.001