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. 2023 Apr 1;15:57. doi: 10.1186/s13148-023-01472-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — NGB-OE inhibits tumor angiogenesis and cell metastasis, which can be rescued by GPR35 re-expression. A The mRNA expression level of GPR35 verified by q-PCR. B Changes of activation factors of angiogenesis pathway examined by WB. C Tube formation restored by GPR35 in NGB overexpression in CRC cells. Statistical analysis of formation and branch counts is shown below. D Cell migration and invasion ability restored by GPR35 overexpression in NGB-OE HCT116 cells. Statistical graphs are shown on the right. All experiments were performed in triplicate. *p < 0.05, **p < 0.01, ***p < 0.001