Figure 2.

Inter-relations of mutation rate, selection coefficient and frequency evolved in a laboratory adaptation experiment (R, Pearson’s correlation coefficient; P, the p-value). From 284 replicate cultures adapted to Rifampicin, Maclean et al. [62] identified 35 different rpoB mutations, many emerging repeatedly, reporting their frequency of evolving (in replicate cultures), and reporting mutation rates for 11 of the variants (frequency evolved is the combined frequency in backgrounds where the mutation is possible, using data in table 1 from Maclean et al. [62]; selection coefficients are averaged when multiple values are reported for different backgrounds). In the three panels, linear regressions were performed on the unlogged values, and Pearson’s correlation coefficients and their respective p-values are shown.