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. 2023 Apr 1;23:298. doi: 10.1186/s12885-023-10721-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — TLR3 and TNBC in FUSCC datasets. The mRNA expression of TLR3 was lower in TNBC tissue than in the adjacent normal tissue (A). The TLR3 had high expression in immunomodulatory (IM) and mesenchymal-like (MES) subtypes and low expression in luminal androgen receptor (LAR) and basal-like immune-suppressed (BLIS) subtypes (B). The expression of TLR3 was positively associated with B cell, CD4 + T cells, CD8 + T cells, neutrophils, macrophages, and myeloid dendritic cells (C). TNBC with high TLR3 expression had a better prognosis than breast cancer with low TLR3 expression (D). TLR3: Toll-like receptor 3; FUSCC: Fudan University Shanghai Cancer Center; TNBC: triple-negative breast cancer; IM: immunomodulatory subtype; MES: mesenchymal-like subtype; LAR: low expression in luminal androgen receptor subtype; BLIS: basal-like immune-suppressed subtype; RFS: relapse-free survival