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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Vascul Pharmacol. 2023 Feb 26;149:107157. doi: 10.1016/j.vph.2023.107157

Fig 2. Functional clinical measurements including 6-minute walk test to determine the efficacy of the treatment with sildenafil were performed in 27 PH patients, before and after treatment with sildenafil.

Fig 2.

Top metabolic correlates to 6MWD included multiple metabolites in fatty acid and arginine metabolism, lipid oxidation products (A). However, patients’ BMI and age were identified as critical covariates impacting such measurements and factors. Patients’ BMI exhibited a significant negative correlation to 6MWD independently of sildenafil treatment and purine levels in B. Patients’ age at least in part impacting the effect of sildenafil on purine metabolism (e.g., adenosine as a function of sildenafil treatment) in C. Adenosine/urate ranked amongst the top correlates to BMI independently from sildenafil treatment in Supplementary Table 1).