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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Vascul Pharmacol. 2023 Feb 26;149:107157. doi: 10.1016/j.vph.2023.107157

Figure 4. Metabolic tracing of U-13C-glucose for 24h reveals incorporation of heavy carbon atoms in de novo synthesized purines through activation of the pentose phosphate pathway and serine metabolism in PH-Fibs.

Figure 4.

An overview of the expected isotopologue distributions is presented in A. Increased serine biosynthesis was observed, along with increased generation of 13C5-ribose phosphate and higher adenosine synthesis in PH-Fibs at 24h from incubation with U-13C-glucose in B. (*, **, *** T-test p <0.05, 0.01, 0.001, respectively; n = 3).