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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Vascul Pharmacol. 2023 Feb 26;149:107157. doi: 10.1016/j.vph.2023.107157

Figure 5. Sildenafil was insufficient to correct metabolic and proliferative state in PH-Fibs.

Figure 5.

Metabolic analysis revealed that treatment with sildenafil did not decrease lactate generation and Krebs cycle aberrations as represented by heat maps (A) and plots (B), as well as purine metabolites (C) in PH-Fibs. (n = 3). (D) Proliferation assay was performed with CyQuant Kit in PH-Fibs with or without treatment of sildenafil (50nM) up to 3 days (n=3). Results were calculated as fold changes relative to day 0. *p <0.05 compared to untreated.