TABLE 1.

Diagnostic significance seen in 15 samples from Todai OncoPanel DNA panel

Cancer type	Pathology	Diagnostic significance
Ovary	Endometrioid	Mutation profile more compatible with endometrioid than high grade serous
Soft tissue	Spindle cell/sclerosing rhabdomyosarcoma	Presence of MYOD1 mutation confirmed the diagnosis
Thyroid	Undifferentiated	PTEN mutation and haploid type more compatible with oncocytic follicular thyroid carcinoma
Kidney	Undetermined	Presence of FH mutation suggests FH‐deficient papillary renal cell cancer
Soft tissue	Undetermined	NF2 mutation suggests mesothelioma
Prostate	Adenocarcinoma	AR amplification suggests resistance to androgen therapy
Brain	Anaplastic astrocytoma	Presence of TERT mutation and absence of TP53 or IDH mutation or 1p/19q codeletion is more compatible with glioblastoma
Kidney	Undetermined	Presence of FH mutation suggests FH‐deficient papillary renal cell cancer
Breast	Ductal carcinoma	Presence of ESR1 mutation suggests resistance to hormone therapy
Soft tissue	Undetermined	Presence of PIK3CA mutation suggests mucinous sarcoma
Unknown primary	Neuroendocrine	Presence of ERBB2 amplification suggests gastric cancer and possible anti‐HER2 therapy
Brain	Glioblastoma	Presence of PTEN and TERT mutations confirms the pathological diagnosis
Duodenum	Adenocarcinoma	Presence of BAP1 mutation suggests bile duct carcinoma
Cervix	Adenocarcinoma	Presence of PGR and PTEN mutations suggests endometrial cancer
Unknown primary	Undetermined	Presence of BCOR mutation suggests renal cell carcinoma