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. 2023 Jan 11;114(4):1396–1409. doi: 10.1111/cas.15695

FIGURE 6.

FIGURE 6

Circ0104103 upregulates beta‐lactamase‐like (LACTB) expression by sponging miR‐373‐5p. (A) Bioinformatics analysis predicted miR‐373‐5p can interact with Circ0104103. (B) MiR‐373‐5p expression was detected by quantitative RT‐PCR (qRT‐PCR) in HCT116 and HCT8 cells after circ0104103 silenced or overexpressed. (C) Dual‐luciferase reporter assays were conducted with wild‐type and mutant‐type (putative binding sites for miR‐373‐5p) luciferase report vectors. (D, E) Beta‐lactamase‐like (LACTB) expression was detected by western blotting in HCT116 cells with indicated treatment. *p < 0.05, **p < 0.01, and ***p < 0.001.