FIGURE 6.

Lenvatinib affects the PI3K/Akt/mTOR signaling pathway by blocking VEGFR2. A, Schematic diagram of the target of each drug. B, Phosphorylations of the mTOR pathway (marked by expression of p‐S6) of pTex and tTex cells in each group were analyzed. Data were expressed as mean ± SEM (n = 5). C, In the different stages of CD8⁺ T cells, the expression of VEGFR2 was analyzed. Data were expressed as mean ± SEM (n = 5). D, Phosphorylations of the mTOR pathway (marked by expression of p‐S6) of pTex and tTex T cells in each group were analyzed. Data were expressed as mean ± SEM (n = 5). *p < 0.05; **p < 0.01; ***p < 0.001, ****p < 0.0001