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. 2022 Dec 26;114(4):1686–1696. doi: 10.1111/cas.15703

FIGURE 3.

FIGURE 3

(A) Sensitivity of cisplatin was suppressed by decreasing the expression of miR‐192‐5p in KYSE170 cells, and sensitivity of cisplatin was promoted by the overexpression of miR‐192‐5p in TE‐15 cells. Experiments were performed in octuplicate and results are shown as mean ± SD. Unpaired t‐test was used to analyze the data (*p < 0.05). (B) Predictive miR‐192‐5p binding sites for ERCC3 and ERCC4 according to TargetScan. (C) Expression levels of ERCC3 and ERCC4 in EC cell lines were evaluated by quantitative (q)RT‐PCR and western blotting (WB). Transfection of miR‐192‐5p inhibitor in KYSE170 cells upregulated the expression of ERCC3 and ERCC4. Conversely, the overexpression of miR‐192‐5p in TE‐15 cells downregulated the expression of ERCC3 and ERCC4. Experiments were performed in triplicate and results are shown as mean ± SD. Unpaired t‐test was used to analyze the data (*p < 0.05; **p < 0.01).