Skip to main content
. 2023 Feb 2;114(4):1582–1595. doi: 10.1111/cas.15723

FIGURE 2.

FIGURE 2

Knockdown of circular RNA ARHGAP5 (circARHGAP5) promoted cervical squamous cell carcinoma drug resistance in vivo and in vitro. (A) Knockdown efficiency of circARHGAP5 shRNAs in SiHa/NC with SiHa/shcircARHGAP5s and ME‐180/NC with ME‐180/shcircARHGAP5s stable cells. (B) Relative change levels of ARHGAP5 in the above two groups of cells. (C) CCK‐8 assays with gradient concentration of cisplatin (CP) in the above two groups of cells. (D, E) Colony formation and apoptosis assays with IC50 concentration of drug cisplatin in the two groups of cells. IC50 for SiHa is 8 μg/ml, and 9 μg/ml for ME‐180. (F) Representative pictures of tumors. (G, H) Weight and volume of the xenograft tumors in the ME‐180/Con and ME180/shcircARHGAP5s cells after 15 days of injection of cisplatin. *p < 0.05, **p < 0.01, ***p < 0.001. Con, control; NC, negative control; ns, not significant; PI, propidium iodide.