FIGURE 3.

Overexpression (OE) of circular RNA ARHGAP5 (circARHGAP5) inhibited cervical squamous cell carcinoma drug resistance. (A) Overexpression efficiency of circARHGAP5 in ME‐180/NC and ME‐180/OE‐circARHGAP5 cells, and SiHa/NC and SiHa/OE‐circARHGAP5 cells. (B) Relative change in ARHGAP5 levels in NC/circ‐OE ME‐180 and SiHa cells. (C) CCK‐8 assay with gradient concentration of cisplatin (CP) in NC/circ‐OE ME‐180 cells and SiHa cells. (D) Apoptosis assays with IC₅₀ concentration of drug cisplatin in NC/circ‐OE ME‐180 cells and SiHa cells. IC₅₀ for SiHa is 8 μg/ml, and 9 μg/ml for ME‐180. *p < 0.05, **p < 0.01, ***p < 0.001. NC, negative control; ns, not significant; PI, propidium iodide.