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Wild-type (left) and mutant (middle and right) Zic2 mutant embryos, showing the range of phenotypes encountered. These include the neural tube defects spina bifida (SB) and exencephaly (EX). The embryo in the middle has severe alobar holoprosencephaly (HPE) with a proboscis, and a pericardial effusion (PE). Dashed lines outline the posterior end of the embryo. Scale bars: 0.5 mm.
