Table 4.
Logistic regression analysis of inflammatory burden index associated with secondary outcomes
| 90‐day outcomes | ||||||
|---|---|---|---|---|---|---|
| IBI | Model a | P value | Model b | P value | Model c | P value |
| Continuous (per SD) | 2.049 (1.727,2.431) | <0.001 | 1.839 (1.541,2.196) | <0.001 | 1.789 (1.489,2.151) | <0.001 |
| Cut‐off value | <0.001 | <0.001 | <0.001 | |||
| C1 (<17) | ref | ref | ref | |||
| C2 (≥17) | 6.564 (4.13,10.432) | 4.551 (2.834,7.309) | 4.037 (2.497,6.527) | <0.001 | ||
| Quartiles | ||||||
| Q1 (<5.23) | ref | ref | ref | |||
| Q2 (5.23–16.38) | 0.564 (0.234,1.357) | 0.2011 | 0.453 (0.186,1.101) | 0.080 | 0.410 (0.168,1.004) | 0.051 |
| Q3 (16.38–80.63) | 2.069 (1.075,3.984) | 0.0295 | 1.439 (0.738,2.805) | 0.286 | 1.152 (0.584,2.274) | 0.683 |
| Q4 (≥80.63) | 8.398 (4.714,14.961) | <0.001 | 4.733 (2.604,8.602) | <0.001 | 3.876 (2.114,7.105) | <0.001 |
| P for trend | <0.001 | <0.001 | <0.001 | |||
| Length of hospitalization (≥14 days), excluding patients with infectious complication (61 cases) | ||||||
|---|---|---|---|---|---|---|
| IBI | Model a | P value | Model b | P value | Model c | P value |
| Continuous (per SD) | 1.103 (0.957,1.271) | 0.175 | 1.101 (0.954,1.27) | 0.187 | 1.099 (0.95,1.271) | 0.204 |
| Cut‐off value | <0.001 | <0.001 | <0.001 | |||
| C1 (<17) | ref | ref | ref | |||
| C2 (≥17) | 1.563 (1.277,1.911) | 1.604 (1.299,1.981) | 1.560 (1.256,1.938) | |||
| Quartiles | ||||||
| Q1 (<5.23) | ref | ref | ref | |||
| Q2 (5.23–16.38) | 1.165 (0.865,1.569) | 0.269 | 1.168 (0.865,1.577) | 0.311 | 1.146 (0.846,1.554) | 0.379 |
| Q3 (16.38–80.63) | 1.471 (1.099,1.968) | 0.010 | 1.497 (1.111,2.016) | 0.008 | 1.430 (1.053,1.941) | 0.022 |
| Q4 (≥80.63) | 1.944 (1.46,2.588) | <0.001 | 2.065 (1.527,2.793) | <0.001 | 1.993 (1.462,2.717) | <0.001 |
| P for trend | <0.001 | <0.001 | <0.001 | |||
| Hospitalization expenses (≥20 000 RMB) | ||||||
|---|---|---|---|---|---|---|
| IBI | Model a | P value | Model b | P value | Model c | P value |
| Continuous (per SD) | 1.212 (1.056,1.392) | 0.006 | 1.206 (1.049,1.386) | 0.009 | 1.198 (1.04,1.381) | 0.012 |
| Cut‐off value | <0.001 | <0.001 | <0.001 | |||
| C1 (<17) | ref | ref | ref | |||
| C2 (≥17) | 1.468 (1.21,1.782) | 1.486 (1.214,1.820) | 1.476 (1.195,1.822) | |||
| Quartiles | ||||||
| Q1 (<5.23) | ref | ref | ref | |||
| Q2 (5.23–16.38) | 1.410 (1.061,1.872) | 0.018 | 1.434 (1.077,1.909) | 0.014 | 1.443 (1.077,1.934) | 0.014 |
| Q3 (16.38–80.63) | 1.470 (1.108,1.951) | 0.008 | 1.514 (1.134,2.023) | 0.005 | 1.498 (1.110,2.023) | 0.008 |
| Q4 (≥80.63) | 2.060 (1.560,2.720) | <0.001 | 2.159 (1.611,2.895) | <0.001 | 2.146 (1.582,2.910) | <0.001 |
| P for trend | <0.001 | <0.001 | <0.001 | |||
| Cachexia | ||||||
|---|---|---|---|---|---|---|
| IBI | Model a | P value | Model b | P value | Model c | P value |
| Continuous (per SD) | 1.388 (1.200,1.606) | <0.001 | 1.237 (1.063,1.439) | 0.006 | 1.223 (1.047,1.427) | 0.011 |
| Cut‐off value | <0.001 | <0.001 | <0.001 | |||
| C1 (<17) | ref | ref | ref | |||
| C2 (≥17) | 2.263 (1.831,2.795) | 1.796 (1.423,2.267) | 1.741 (1.374,2.207) | |||
| Quartiles | ||||||
| Q1 (<5.23) | ref | ref | ref | |||
| Q2 (5.23–16.38) | 1.184 (0.852,1.645) | 0.3149 | 1.138 (0.801,1.616) | 0.470 | 1.124 (0.790,1.599) | 0.517 |
| Q3 (16.38–80.63) | 1.84 (1.346,2.517) | <0.001 | 1.593 (1.138,2.232) | 0.007 | 1.529 (1.086,2.154) | 0.015 |
| Q4 (≥80.63) | 3.418 (2.528,4.623) | <0.001 | 2.403 (1.724,3.351) | <0.001 | 2.318 (1.654,3.248) | <0.001 |
| P for trend | <0.001 | <0.001 | <0.001 | |||
Model a: No adjusted. Model b: Adjusted for age, sex, BMI, TNM stage. Model c: Adjusted for age, sex, BMI, TNM stage, surgery, radiotherapy, chemotherapy, hypertension, diabetes, smoking, drinking, family history.