Table 1.
(A) Biochemical and physiological parameters of the three experimental groups: Young mice, old mice (Old‐24m) and old mice fed with the hypophosphataemic diet (Old‐LowP); and (B) the Pearson correlation coefficients (r), and its P value (P), between serum concentration of phosphate and gastrocnemius mass, tibialis mass, mean fibre cross‐sectional area (FCSA), Sirius red intensity, tetanic force, gait speed, orientation time and transition time, obtained from all animals fed with the pellet diet.
| (A) Biochemical and physiological parameters | |||
|---|---|---|---|
| Young | Old‐24m | Old‐LowP | |
| Serum P levels (mg/dL) | 16.46 ± 0.77 (n = 15) | 21.24 ± 0.95* (n = 21) | 17.46 ± 0.82 # (n = 22) |
| Body weight (g) | 33.64 ± 0.72 (n = 19) | 34.19 ± 1.15 (n = 21) | 33.10 ± 1.05 (n = 24) |
| Body mass index (g/cm2) | 3.51 ± 0.07 (n = 19) | 3.38 ± 0.11 (n = 21) | 3.27 ± 0.08 (n = 24) |
| Blood glucose (mg/dL) | 173.00 ± 10.43 (n = 5) | 159.00 ± 7.33 (n = 8) | 160.00 ± 5.73 (n = 9) |
| Beats per minute | 654.50 ± 7.79 (n = 14) | 659.00 ± 10.13 (n = 16) | 663.70 ± 4.76 (n = 9) |
| Systolic blood pressure (mmHg) | 115.00 ± 0.939 (n = 14) | 101.00 ± 2.15* (n = 16) | 101.50 ± 3.55* (n = 9) |
| Diastolic blood pressure (mmHg) | 76.50 ± 1.67 (n = 14) | 69.43 ± 1.58* (n = 16) | 71.87 ± 1.97 (n = 9) |
| (B) Correlation between serum phosphate levels and sarcopenia signs | |||
|---|---|---|---|
| Serum phosphate levels | |||
| r | P | n | |
| Gastrocnemius mass | −0.390 | 0.001 | 68 |
| Tibialis mass | −0.322 | 0.006 | 68 |
| Mean FCSA | −0.390 | 0.019 | 36 |
| Sirius red intensity | 0.398 | 0.020 | 34 |
| Tetanic force | −0.682 | >0.001 | 36 |
| Gait speed | −0.534 | >0.001 | 65 |
| Transition time | 0.491 | >0.001 | 58 |
Note: Results are expressed as mean ± standard error.
*
P < 0.05 versus Young.
#
P < 0.05 versus Old‐24m.