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. 2023 Feb 11;14(2):730–744. doi: 10.1002/jcsm.13189

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© 2023 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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CAF and ageing, sarcopenia, disease and physical activity and inactivity. Schematic representation of CAF concentration measurement and the main findings provided by the literature. On the left side of the picture: Physical inactivity, ageing and sarcopenia, muscle‐wasting disease (in grey), as the conditions in which CAF has been reported to increase or be higher than controls. On the right side of the picture: Physical activity and dance (in blue), as the conditions in which CAF has been mainly reported to be either maintained or reduced. WB, western blot; ELISA, enzyme‐linked immunosorbent assay; ULLS, unilateral lower limb suspension; CAF, C‐terminal agrin fragment.