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. 2023 Mar 1;14(2):964–977. doi: 10.1002/jcsm.13178

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© 2023 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Transcriptome analysis of IBM and CTL fibroblasts (n = 3/group). (A) Principal component analysis (PCA) of affected (IBM) versus unaffected (CTL) subjects. (B) Heatmap of the top 50 differentially expressed genes (DEGs) obtained in a differential expression analysis between both cohorts. All DEGs are represented in Table S1. (C) Top pathways (with lowest P‐value adj) after a functional gene set enrichment analysis (GSEA) and considering their normalized enrichment score (NES). PCA, heatmap and pathway analysis revealed a differential gene expression pattern in IBM patients, with DEGs and pathways related to inflammation, mitochondria and other processes like cell cycle regulation and metabolism of amino acids and derivatives.