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. 2023 Mar 28;220(7):e20222052. doi: 10.1084/jem.20222052

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© 2023 Benoist et al.

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Figure S2. — Short-term responses to IL2/anti-IL2 complexes. Comparison of changes induced by pure recombinant mIL2 injected alone or complexed with two anti-IL2 antibodies (JES6 and S4B6) that allow IL2 signaling with preference for the CD25 or CD122 forms. Complexes were formed under the conditions of Spangler et al. (2015b), but we cannot be sure that no free IL2 dissociates after injection, possibly explaining the surprisingly similar profiles.