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. 2023 Mar 20;14:1115794. doi: 10.3389/fimmu.2023.1115794

Figure 2.

Figure 2

The PADI family is involved in the secretion of inflammatory cytokines. In immune cells, PADI2 can mediate Jurkat apoptosis through the citrullination of vimentin. PADI2 can be used to citrullinate GATA3. RORγt determines the differentiation direction of Th cells and affects the secretion of inflammatory cytokines. PADI4 can directly affect the secretion of inflammatory cytokines in macrophages. PADI2 can cooperate with PADI4 to affect the assembly of macrophage inflammatory bodies, mediate the dissociation of PAI-2 and PSMB1, and promote the secretion of inflammatory cytokines. In nonimmune cells, PADI2 can promote the secretion of inflammatory cytokines by targeting histones and can also act as an epigenetic coactivator to promote the signal transduction of inflammatory cytokines. PADI4 can promote the binding of BRD4 and E2F-1 and promote the secretion of inflammatory cytokines. PADI4 can also target NF-κB p65 to promote the secretion of inflammatory cytokines.