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. 2023 Mar 20;14:1115794. doi: 10.3389/fimmu.2023.1115794

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Copyright © 2023 Zhu, Liu and Chai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between PADI family and human diseases. The genetic variation of PADI family will endow with the susceptibility of inflammatory autoimmune diseases and cancer. PADI family can participate in inflammatory autoimmune diseases through NETosis and inflammatory cytokines. PADI family can participate in cancer through NETosis, inflammatory cytokines, energy metabolism, EV, signal transduction and gene expression regulation. PADI family can participate in reproductive and development-related diseases through gene expression regulation.